Development of a Radiolabeled Folate-Mediated Drug Delivery System for Effective Delivery of Docetaxel

Many preclinical studies are carried out with the aim of developing new formulations for effective delivery taxane class drugs, one most important anticancer drugs used clinically today. In this study, a radiolabeled folate-mediated solid lipid magnetic nanoparticle (SLMNP) system was developed by loading superparamagnetic iron oxide nanoparticles (MNP) and docetaxel (DTX) into as drug that will function both in cancer treatment diagnosis. For purpose, first, SLMNP synthesized hot homogenization method, surface particles modified folate derivative to carry tissues receptors. The were loaded DTX, then radiolabeling technetium-99 m (99mTc-DTX-SLMNP). Structural characteristics these determined characterization methods. According TEM images MNPs, SLN, SLMNPs, MNPs observed between 25and 35 nm, SLNs 400 500 SLMNPs 350 450 nm. entrapment efficiency DTX found be 19%, percentage 98.0 ± 2.0%. biological behavior investigated vitro vivo. Folate receptor-positive SKOV-3 receptor-negative A549 cell lines studied. IC50 values DTX-SLMNP cells 50.21 172.27 μM at 48 h, respectively. Gamma camera imaging 99mTc-DTX-SLMNP magnetically applied compounds performed on tumor-bearing CD-1 nude mice. uptake tumor region higher than receptor negative region. We proposed we prepared study evaluated carrier drugs.